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Microscopic images of a normal heart valve in a mouse, left, and a heart valve grown in a lab with heart-derived macrophages blocked, right. Without those macrophages, the valves are thick and deformed.
Dr. Steven Dubinett
A mouse heart with cardiomyocytes dissolved, leaving a 3-D scaffold of cardiac fibroblasts. Concentrated areas of red represent post-heart attack aggregation of cardiac fibroblasts.
Researchers led by Dr. Reza Ardehali used four different fluorescent-colored proteins to determine the origin of cardiomyocytes in mice.
Human heart cells grown from stem cells show less robust muscle fibers (green) in high glucose conditions (left) compared to reduced glucose conditions (right).
Microscope image of cardiac calcification in a mouse showing cardiac fibroblasts (red) expressing the ENPP1 protein (green and yellow)
3-D bioengineered lung-like tissue (left) resembles adult human lung (right).
Researchers observed clusters of cardiac muscle cells (in red and green) derived from human embryonic stem cells 40 days after transplantation.