CELEBRATING 20 YEARS OF TRANSFORMATIVE STEM CELL RESEARCH
DIVE INTO THE DIGITAL REPORT

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Left to right: Zika virus (green) infects and destroys the formation of neurons (pink) in human stem cell-derived brain organoids. Administration of 25HC blocks Zika infection and preserves neuron formation in the organoids. Reduced brain size and structure in a Zika-infected mouse brain. Administration of 25HC preserves mouse brain size and structure.
At left, head and neck squamous cell carcinoma invasive growth, and at right, cancer stem cells (shown in red) in head and neck squamous cell carcinoma.
T cell graphic image
The new protocol turned 90 percent of human pluripotent stem cells into somite cells in just four days; those somite cells then generated (left to right) cartilage, bone and muscle cells.
From left: senior authors Kathrin Plath and Jason Ernst and first authors Petko Fiziev and Constantinos Chronis
Migration of TCA cycle protein from the mitochondria (left, green) to the nuclei (right, red) in the two-cell stage mouse embryo.
Left: Primed human embryonic stem cells have one active X chromosome (one red dot in each blue nucleus). Right: Naive human embryonic stem cells have two active X chromosomes (two red dots in each blue nucleus).
Andrew Goldstein photographed in a UCLA lab.
After radiation, blood cells (purple) regenerated in the bone marrow of mice that were given DKK1 intravenously (left), but not in those that received saline solution (right).