CELEBRATING 20 YEARS OF TRANSFORMATIVE STEM CELL RESEARCH
DIVE INTO THE DIGITAL REPORT

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Human embryonic stem cell-derived neurons (green) showing nuclei in blue. Left: with retinoic acid added. Right: with retinoic acid and BMP4 added, creating proprioceptive sensory interneurons (pink).
Skeletal muscle cells isolated using the ERBB3 and NGFR surface markers (right) restore human dystrophin (green) after transplantation significantly greater than previous methods (left).
Untreated mouse skin showing no hair growth (left) compared to mouse skin treated with the drug UK5099 (right) showing hair growth.
The new protocol turned 90 percent of human pluripotent stem cells into somite cells in just four days; those somite cells then generated (left to right) cartilage, bone and muscle cells.
From left: senior authors Kathrin Plath and Jason Ernst and first authors Petko Fiziev and Constantinos Chronis
Left: Primed human embryonic stem cells have one active X chromosome (one red dot in each blue nucleus). Right: Naive human embryonic stem cells have two active X chromosomes (two red dots in each blue nucleus).
After radiation, blood cells (purple) regenerated in the bone marrow of mice that were given DKK1 intravenously (left), but not in those that received saline solution (right).
Colorful staining indicates higher levels of a key sugar metabolism regulator in naïve (bottom row) versus primed (top row) human embryonic stem cells.
Primed human embryonic stem cells (purple) surrounded by a stem cell surface marker (green), which would be missing in naïve embryonic stem cells.