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Microscopic images of human stem cell–derived airway tissue models with cell nuclei (blue) and SARS-CoV-2 virus infected cells (green); tissue exposed to cigarette smoke (right) had 2 to 3 times more infected cells than non-exposed tissue (left).
Microscopic image showing stem cells in young (left) and old (right) airways with cell nuclei seen in blue, airway basal stem cells seen in red and ciliated cells seen in green.
Electron microscopy images showing a healthy scar containing collagen type 5 with scar fibers smoothly arranged in parallel (left) and unhealthy scar containing no collagen type 5 with a disorganized architecture with disarray of scar fibers (right).
Human induced pluripotent stem cell-derived cardiomyocytes (heart cells) shown in green and blue, are infected by the novel coronavirus SARS-CoV-2 (red)
Normal airway tissue, left, and lung cancer tissue, right, with an overabundance of basal stem cells (green). The activated form of beta-catenin (red) in the lung cancer can be targeted by the Wnt Inhibitor Compound 1.
Microscopic images of a normal heart valve in a mouse, left, and a heart valve grown in a lab with heart-derived macrophages blocked, right. Without those macrophages, the valves are thick and deformed.
Dr. Steven Dubinett
A mouse heart with cardiomyocytes dissolved, leaving a 3-D scaffold of cardiac fibroblasts. Concentrated areas of red represent post-heart attack aggregation of cardiac fibroblasts.
Researchers led by Dr. Reza Ardehali used four different fluorescent-colored proteins to determine the origin of cardiomyocytes in mice.