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Increasing the concentration of a certain type of BMP increases the production of the same categories of sensory interneurons (red and green). Left: no BMP added; center: 1x BMP added; right: 10x BMP added.
Untreated mouse skin showing no hair growth (left) compared to mouse skin treated with the drug UK5099 (right) showing hair growth.
Illustration of mice adapting to their custom-designed space habitat on board the International Space Station
Left: axons (green, pink, blue) form organized patterns in the normal developing mouse spinal cord. Right: removing netrin1 results in highly disorganized axon growth.
T cells (red) produced using artificial thymic organoids developed at UCLA.
Left to right: Zika virus (green) infects and destroys the formation of neurons (pink) in human stem cell-derived brain organoids. Administration of 25HC blocks Zika infection and preserves neuron formation in the organoids. Reduced brain size and structure in a Zika-infected mouse brain. Administration of 25HC preserves mouse brain size and structure.
At left, head and neck squamous cell carcinoma invasive growth, and at right, cancer stem cells (shown in red) in head and neck squamous cell carcinoma.
The new protocol turned 90 percent of human pluripotent stem cells into somite cells in just four days; those somite cells then generated (left to right) cartilage, bone and muscle cells.
From left: senior authors Kathrin Plath and Jason Ernst and first authors Petko Fiziev and Constantinos Chronis