Clemence Bonnet, M.D., Ph.D.
- Assistant Professor, Ophthalmology
Research Areas
Clemence Bonnet, M.D., Ph.D., investigates the role of the Wnt signaling pathway in limbal stem cell function, aiming to uncover the mechanisms that regulate these cells’ proliferation. Her research could lead to new therapies for treating partial limbal stem cell deficiency, a condition that can result in vision loss due to impaired corneal regeneration.
Bonnet specializes in the clinical and surgical treatment of corneal diseases. Her expertise spans a range of surgical interventions, including endothelial keratoplasty, deep anterior lamellar keratoplasty, limbal stem cell transplantation, artificial cornea implantation, refractive surgery, cross-linking and cataract surgery.
Beyond her clinical work, Bonnet is advancing ophthalmic research by investigating how Wnt signaling can enhance limbal stem cell proliferation as a new therapeutic strategy for limbal stem cell deficiency. She also applies multi-modal corneal imaging to improve disease diagnosis and monitoring and is integrating artificial intelligence tools to automate the quantification of biomarkers related to limbal stem cell function and corneal health. Through this work, she hopes to pave the way for more precise and personalized treatments.
Research Projects
- Enhancing in vitro A process, procedure or study performed in a test tube or lab dish rather than in a living organism. in vitro A process, procedure or study performed in a test tube or lab dish rather than in a living organism. and in vivo A process, procedure or study performed on or in a living organism. in vivo A process, procedure or study performed on or in a living organism. limbal stem cell proliferation by activating the Wnt signaling pathway
- Developing new treatments for partial limbal stem cell deficiency using limbal stem cell secretome and Wnt-enriched secretome
- Creating AI-based tools to automate the quantification of biomarkers for limbal stem cell function and corneal epithelial health
- Establishing in vitro biomarkers of limbal stem cell function to assess stemness Refers to the unique properties that define a stem cell, including its ability to self-renew and differentiate into multiple specialized cell types. Stemness is regulated by genetic and molecular factors that maintain a stem cell’s identity and potential. stemness Refers to the unique properties that define a stem cell, including its ability to self-renew and differentiate into multiple specialized cell types. Stemness is regulated by genetic and molecular factors that maintain a stem cell’s identity and potential. during stem cell proliferation
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Fellowships
- Cornea and Refractive Surgery, UCLA Jules Stein Eye Institute, 2019
- Ophthalmology, Universite Rene Descartes (Paris V), France, 2018
Residency
- Ophthalmology, Pierre and Marie Curie University (Paris VI), France, 2015
Degrees
- Ph.D., Cell Biology, University of California Los Angeles, 2022
- M.D., University of Rouen School of Medicine, France, 2010