Alexander Hoffmann, Ph.D.

Hoffmann has been at the forefront of systems biology approaches for over 20 years, integrating quantitative experimentation and mathematical modeling into his research on immune signaling and regulatory networks. He aims to develop a predictive understanding of the signaling systems that control immune responses, spanning from biophysical interactions at the molecular level to high-level interactions between numerous cells in immune organs, such as the thymus or spleen. 

His research integrates a wide array of experimental work in animals and cell culture, ranging from single-molecule to genome-wide scales, with computational modeling. Hoffmann has contributed significantly to understanding how NFκB and IRF signaling dynamics are regulated; how these change during cell differentiation and in human disease contexts; and how rational drug targeting strategies may be applied to correct misregulation.

Currently, Hoffmann's research focuses on three main areas: macrophages, B-cells and hematopoiesis, or blood cell production. In studying macrophages, he seeks to develop a predictive understanding of their inflammatory and immune functions, addressing both acute responses to pathogens and long-term adaptation. This research could thereby enable targeted innate immune training strategies. His B-cell research centers on understanding the mechanisms of antibody responses, with the goal of enabling precision vaccination strategies. In the context of hematopoiesis, he examines how inflammation affects the process of blood stem cell formation and the biology of underlying stem and progenitor cells. 

As immune responses play a crucial role in various diseases, from cancer to autoimmune disorders, insights gained from Hoffmann’s work may lead to new targeted therapies for various immune-related diseases.